Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
Identifieur interne : 008225 ( Main/Exploration ); précédent : 008224; suivant : 008226Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
Auteurs : Dinesh Khanna [États-Unis, Suisse, France, Allemagne, Royaume-Uni, Pologne, Italie, Australie, Canada] ; Oliver Distler ; Jerome Avouac ; Frank Behrens ; Philip J. Clements ; Christopher Denton ; Ivan Foeldvari ; Edward Giannini ; Doerte Huscher ; Otylia Kowal-Bielecka ; Daniel Lovell ; Marco Matucci-Cerinic ; Maureen Mayes ; Peter A. Merkel ; Peter Nash ; Christian F. Opitz ; David Pittrow ; Lewis Rubin ; James R. Seibold ; Virginia Steen ; C. Vibeke Strand ; Peter S. Tugwell ; John Varga ; Angela Zink ; Daniel E. FurstSource :
- Journal of rheumatology [ 0315-162X ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
There have been steady efforts to develop a combined response index for systemic sclerosis (CRISS). A parallel and equally successful effort has been made by an Expert Panel on Outcome Measures in PAH related to Systemic Sclerosis (EPOSS) to measure effect in treatment of pulmonary arterial hypertension of systemic sclerosis (PAH-SSc). CRISS conducted a Delphi process combined with expert review to identify 11 candidate domains for inclusion in a core set of outcomes for SSc clinical trials: soluble biomarkers, cardiac, digital ulcers, gastrointestinal, global health, health related quality of life (HRQOL) and function, musculoskeletal, pulmonary, Raynaud's, renal, and skin. Tools within domains were also agreed upon. Concentrating on one aspect of disease, PAH, EPOSS also conducted a Delphi process and judged the following domains as the most appropriate for randomized controlled trials in PAH-SSc: lung vascular/pulmonary arterial pressure, cardiac function, exercise testing; severity of dyspnea, discontinuation of treatment; quality of life/activities of daily living; global state; and survival. Possible useful tools within each domain were also agreed on. Patient derived, physician derived, and objective measures of response will be included and combined with the idea that each reflects different aspects of PAH (EPOSS) and overall disease (CRISS) although this assumption may not prove true and can be separated if statistically and clinically valid to do so. In either case, prospective studies will require measurement of all domains, and tools are required and will be developed to define appropriate combined measures of response. CRISS and EPOSS are being developed through the OMERACT process. Through Delphi process and literature review significant progress has been made for both indices, and prospective data are being collected.
Affiliations:
- Allemagne, Australie, Canada, France, Italie, Pologne, Royaume-Uni, Suisse, États-Unis
- Angleterre, Berlin, Californie, District de Darmstadt, Grand Londres, Hesse (Land), Massachusetts, Michigan, Ohio, Île-de-France
- Berlin, Francfort-sur-le-Main, Londres, Paris, San Diego
Links toward previous steps (curation, corpus...)
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Merkel</name></author><author><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name></author><author><name sortKey="Opitz, Christian F" sort="Opitz, Christian F" uniqKey="Opitz C" first="Christian F." last="Opitz">Christian F. Opitz</name></author><author><name sortKey="Pittrow, David" sort="Pittrow, David" uniqKey="Pittrow D" first="David" last="Pittrow">David Pittrow</name></author><author><name sortKey="Rubin, Lewis" sort="Rubin, Lewis" uniqKey="Rubin L" first="Lewis" last="Rubin">Lewis Rubin</name></author><author><name sortKey="Seibold, James R" sort="Seibold, James R" uniqKey="Seibold J" first="James R." last="Seibold">James R. Seibold</name></author><author><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name></author><author><name sortKey="Vibeke Strand, C" sort="Vibeke Strand, C" uniqKey="Vibeke Strand C" first="C." last="Vibeke Strand">C. Vibeke Strand</name></author><author><name sortKey="Tugwell, Peter S" sort="Tugwell, Peter S" uniqKey="Tugwell P" first="Peter S." last="Tugwell">Peter S. Tugwell</name></author><author><name sortKey="Varga, John" sort="Varga, John" uniqKey="Varga J" first="John" last="Varga">John Varga</name></author><author><name sortKey="Zink, Angela" sort="Zink, Angela" uniqKey="Zink A" first="Angela" last="Zink">Angela Zink</name></author><author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0429665</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0429665 INIST</idno><idno type="RBID">Pascal:09-0429665</idno><idno type="wicri:Area/PascalFrancis/Corpus">002B20</idno><idno type="wicri:Area/PascalFrancis/Curation">003504</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002A08</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002A08</idno><idno type="wicri:doubleKey">0315-162X:2009:Khanna D:measures:of:response</idno><idno type="wicri:Area/Main/Merge">008977</idno><idno type="wicri:Area/Main/Curation">008225</idno><idno type="wicri:Area/Main/Exploration">008225</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)</title><author><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>David Geffen School at University of California</s1><s2>Los Angeles, CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>David Geffen School at University of California</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>University Hospital Zurich</s1><s2>Zurich</s2><s3>CHE</s3></inist:fA14><country>Suisse</country><wicri:noRegion>University Hospital Zurich</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP</s1><s2>Paris</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Goethe University</s1><s2>Frankfurt</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Royal Free and University College Medical School</s1><s2>London</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>General Hospital Eilbek</s1><s2>Eilbek</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Eilbek</wicri:noRegion><wicri:noRegion>General Hospital Eilbek</wicri:noRegion><wicri:noRegion>General Hospital Eilbek</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Rehabilitation Institute, UCLA</s1><s2>Los Angeles, CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Los Angeles, CA</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Cincinnati Children's Hospital Medical Center</s1><s2>Cincinnati, Ohio</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>German Arthritis Research Centre</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Rheumatology and Internal Medicine, Medical University of Bialystok</s1><s2>Bialystok</s2><s3>POL</s3></inist:fA14><country>Pologne</country><wicri:noRegion>Bialystok</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Division of Medicine and Rheumatology, University of Florence</s1><s2>Florence</s2><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Rheumatology, University of Texas Health Science Center at Houston</s1><s2>Houston, TX</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, TX</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Queensland</s1><s2>Queensland</s2><s3>AUS</s3></inist:fA14><country>Australie</country><wicri:noRegion>University of Queensland</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Deutsches Herzzentrum Berlin</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Clinical Pharmacology, Medical Faculty, Technical University of Dresden</s1><s2>San Diego</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">San Diego</settlement><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Department of Internal Medicine, University of Michigan</s1><s2>Ann Arbor, Michigan</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Division of Rheumatology, Georgetown University Hospital</s1><s2>Washington, DC</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Washington, DC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Division of Immunology, Stanfard University</s1><s2>Portola Valley, CA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Portola Valley, CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Institute of Population Health</s1><s2>Ottawa, ON</s2><s3>CAN</s3></inist:fA14><country>Canada</country><wicri:noRegion>Institute of Population Health</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Feinberg School of Medicine, Northwestern School of Medicine</s1><s2>Chicago, IL</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Chicago, IL</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="22"><s1>German Rheumatism Research Centre</s1><s2>Berlin</s2><s3>DEU</s3></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name></author><author><name sortKey="Avouac, Jerome" sort="Avouac, Jerome" uniqKey="Avouac J" first="Jerome" last="Avouac">Jerome Avouac</name></author><author><name sortKey="Behrens, Frank" sort="Behrens, Frank" uniqKey="Behrens F" first="Frank" last="Behrens">Frank Behrens</name></author><author><name sortKey="Clements, Philip J" sort="Clements, Philip J" uniqKey="Clements P" first="Philip J." last="Clements">Philip J. Clements</name></author><author><name sortKey="Denton, Christopher" sort="Denton, Christopher" uniqKey="Denton C" first="Christopher" last="Denton">Christopher Denton</name></author><author><name sortKey="Foeldvari, Ivan" sort="Foeldvari, Ivan" uniqKey="Foeldvari I" first="Ivan" last="Foeldvari">Ivan Foeldvari</name></author><author><name sortKey="Giannini, Edward" sort="Giannini, Edward" uniqKey="Giannini E" first="Edward" last="Giannini">Edward Giannini</name></author><author><name sortKey="Huscher, Doerte" sort="Huscher, Doerte" uniqKey="Huscher D" first="Doerte" last="Huscher">Doerte Huscher</name></author><author><name sortKey="Kowal Bielecka, Otylia" sort="Kowal Bielecka, Otylia" uniqKey="Kowal Bielecka O" first="Otylia" last="Kowal-Bielecka">Otylia Kowal-Bielecka</name></author><author><name sortKey="Lovell, Daniel" sort="Lovell, Daniel" uniqKey="Lovell D" first="Daniel" last="Lovell">Daniel Lovell</name></author><author><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name></author><author><name sortKey="Mayes, Maureen" sort="Mayes, Maureen" uniqKey="Mayes M" first="Maureen" last="Mayes">Maureen Mayes</name></author><author><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name></author><author><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name></author><author><name sortKey="Opitz, Christian F" sort="Opitz, Christian F" uniqKey="Opitz C" first="Christian F." last="Opitz">Christian F. Opitz</name></author><author><name sortKey="Pittrow, David" sort="Pittrow, David" uniqKey="Pittrow D" first="David" last="Pittrow">David Pittrow</name></author><author><name sortKey="Rubin, Lewis" sort="Rubin, Lewis" uniqKey="Rubin L" first="Lewis" last="Rubin">Lewis Rubin</name></author><author><name sortKey="Seibold, James R" sort="Seibold, James R" uniqKey="Seibold J" first="James R." last="Seibold">James R. Seibold</name></author><author><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name></author><author><name sortKey="Vibeke Strand, C" sort="Vibeke Strand, C" uniqKey="Vibeke Strand C" first="C." last="Vibeke Strand">C. Vibeke Strand</name></author><author><name sortKey="Tugwell, Peter S" sort="Tugwell, Peter S" uniqKey="Tugwell P" first="Peter S." last="Tugwell">Peter S. Tugwell</name></author><author><name sortKey="Varga, John" sort="Varga, John" uniqKey="Varga J" first="John" last="Varga">John Varga</name></author><author><name sortKey="Zink, Angela" sort="Zink, Angela" uniqKey="Zink A" first="Angela" last="Zink">Angela Zink</name></author><author><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name></author></analytic><series><title level="j" type="main">Journal of rheumatology</title><title level="j" type="abbreviated">J. rheumatol.</title><idno type="ISSN">0315-162X</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of rheumatology</title><title level="j" type="abbreviated">J. rheumatol.</title><idno type="ISSN">0315-162X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Artery</term><term>Clinical trial</term><term>Prognosis</term><term>Pulmonary hypertension</term><term>Rheumatology</term><term>Scleroderma</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Essai clinique</term><term>Sclérodermie</term><term>Pronostic</term><term>Hypertension artérielle pulmonaire</term><term>Artère</term><term>Rhumatologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There have been steady efforts to develop a combined response index for systemic sclerosis (CRISS). A parallel and equally successful effort has been made by an Expert Panel on Outcome Measures in PAH related to Systemic Sclerosis (EPOSS) to measure effect in treatment of pulmonary arterial hypertension of systemic sclerosis (PAH-SSc). CRISS conducted a Delphi process combined with expert review to identify 11 candidate domains for inclusion in a core set of outcomes for SSc clinical trials: soluble biomarkers, cardiac, digital ulcers, gastrointestinal, global health, health related quality of life (HRQOL) and function, musculoskeletal, pulmonary, Raynaud's, renal, and skin. Tools within domains were also agreed upon. Concentrating on one aspect of disease, PAH, EPOSS also conducted a Delphi process and judged the following domains as the most appropriate for randomized controlled trials in PAH-SSc: lung vascular/pulmonary arterial pressure, cardiac function, exercise testing; severity of dyspnea, discontinuation of treatment; quality of life/activities of daily living; global state; and survival. Possible useful tools within each domain were also agreed on. Patient derived, physician derived, and objective measures of response will be included and combined with the idea that each reflects different aspects of PAH (EPOSS) and overall disease (CRISS) although this assumption may not prove true and can be separated if statistically and clinically valid to do so. In either case, prospective studies will require measurement of all domains, and tools are required and will be developed to define appropriate combined measures of response. CRISS and EPOSS are being developed through the OMERACT process. Through Delphi process and literature review significant progress has been made for both indices, and prospective data are being collected.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>France</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Californie</li><li>District de Darmstadt</li><li>Grand Londres</li><li>Hesse (Land)</li><li>Massachusetts</li><li>Michigan</li><li>Ohio</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Francfort-sur-le-Main</li><li>Londres</li><li>Paris</li><li>San Diego</li></settlement></list><tree><noCountry><name sortKey="Avouac, Jerome" sort="Avouac, Jerome" uniqKey="Avouac J" first="Jerome" last="Avouac">Jerome Avouac</name><name sortKey="Behrens, Frank" sort="Behrens, Frank" uniqKey="Behrens F" first="Frank" last="Behrens">Frank Behrens</name><name sortKey="Clements, Philip J" sort="Clements, Philip J" uniqKey="Clements P" first="Philip J." last="Clements">Philip J. Clements</name><name sortKey="Denton, Christopher" sort="Denton, Christopher" uniqKey="Denton C" first="Christopher" last="Denton">Christopher Denton</name><name sortKey="Distler, Oliver" sort="Distler, Oliver" uniqKey="Distler O" first="Oliver" last="Distler">Oliver Distler</name><name sortKey="Foeldvari, Ivan" sort="Foeldvari, Ivan" uniqKey="Foeldvari I" first="Ivan" last="Foeldvari">Ivan Foeldvari</name><name sortKey="Furst, Daniel E" sort="Furst, Daniel E" uniqKey="Furst D" first="Daniel E." last="Furst">Daniel E. Furst</name><name sortKey="Giannini, Edward" sort="Giannini, Edward" uniqKey="Giannini E" first="Edward" last="Giannini">Edward Giannini</name><name sortKey="Huscher, Doerte" sort="Huscher, Doerte" uniqKey="Huscher D" first="Doerte" last="Huscher">Doerte Huscher</name><name sortKey="Kowal Bielecka, Otylia" sort="Kowal Bielecka, Otylia" uniqKey="Kowal Bielecka O" first="Otylia" last="Kowal-Bielecka">Otylia Kowal-Bielecka</name><name sortKey="Lovell, Daniel" sort="Lovell, Daniel" uniqKey="Lovell D" first="Daniel" last="Lovell">Daniel Lovell</name><name sortKey="Matucci Cerinic, Marco" sort="Matucci Cerinic, Marco" uniqKey="Matucci Cerinic M" first="Marco" last="Matucci-Cerinic">Marco Matucci-Cerinic</name><name sortKey="Mayes, Maureen" sort="Mayes, Maureen" uniqKey="Mayes M" first="Maureen" last="Mayes">Maureen Mayes</name><name sortKey="Merkel, Peter A" sort="Merkel, Peter A" uniqKey="Merkel P" first="Peter A." last="Merkel">Peter A. Merkel</name><name sortKey="Nash, Peter" sort="Nash, Peter" uniqKey="Nash P" first="Peter" last="Nash">Peter Nash</name><name sortKey="Opitz, Christian F" sort="Opitz, Christian F" uniqKey="Opitz C" first="Christian F." last="Opitz">Christian F. Opitz</name><name sortKey="Pittrow, David" sort="Pittrow, David" uniqKey="Pittrow D" first="David" last="Pittrow">David Pittrow</name><name sortKey="Rubin, Lewis" sort="Rubin, Lewis" uniqKey="Rubin L" first="Lewis" last="Rubin">Lewis Rubin</name><name sortKey="Seibold, James R" sort="Seibold, James R" uniqKey="Seibold J" first="James R." last="Seibold">James R. Seibold</name><name sortKey="Steen, Virginia" sort="Steen, Virginia" uniqKey="Steen V" first="Virginia" last="Steen">Virginia Steen</name><name sortKey="Tugwell, Peter S" sort="Tugwell, Peter S" uniqKey="Tugwell P" first="Peter S." last="Tugwell">Peter S. Tugwell</name><name sortKey="Varga, John" sort="Varga, John" uniqKey="Varga J" first="John" last="Varga">John Varga</name><name sortKey="Vibeke Strand, C" sort="Vibeke Strand, C" uniqKey="Vibeke Strand C" first="C." last="Vibeke Strand">C. Vibeke Strand</name><name sortKey="Zink, Angela" sort="Zink, Angela" uniqKey="Zink A" first="Angela" last="Zink">Angela Zink</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></country><country name="Suisse"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></region></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></region><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></region></country><country name="Pologne"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Khanna, Dinesh" sort="Khanna, Dinesh" uniqKey="Khanna D" first="Dinesh" last="Khanna">Dinesh Khanna</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Measures of Response in Clinical Trials of Systemic Sclerosis: The Combined Response Index for Systemic Sclerosis (CRISS) and Outcome Measures in Pulmonary Arterial Hypertension Related to Systemic Sclerosis (EPOSS)
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